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The question
Three days after a large paracetamol (acetaminophen) overdose, a 24-year-old woman has: INR 4.6 (reference 0.9-1.1), factor V 14%, factor VII 9%, factor VIII 190% (all 50-150%), platelets 150 × 10^9/L and fibrinogen 1.5 g/L (150 mg/dL; reference 2.0-4.0 g/L). Which mechanism best explains these results?
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