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Ninety minutes after receiving one apheresis platelet unit and two plasma units, a 58-year-old man develops severe hypoxemia (SpO2 82% on room air), fever, hypotension and new bilateral infiltrates. BNP is normal and he is not fluid overloaded. The donors are tested. Recipient HLA type: A1, A3; B8, B44; DR4, DR15. Donor 1, male (plasma): no HLA or HNA antibodies. Donor 2, female (platelets): anti-HLA-A2 and anti-HLA-DR4. Donor 3, female, never pregnant (plasma): no HLA or HNA antibodies. Which conclusion is best supported?
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